Cannabinoids and The Entourage Effect
Though many consumers, extractors and even government agencies are learning more about isolated cannabinoids; it seems that they work best together.
The Entourage Effect was first introduced into the scientific cannabis community in 1998 by S. Ben-Shabat with Raphael Mechoulam. The concept is of an endogenous cannabinoid molecular regulation route that remains novel to cannabis science almost twenty years later. This route promotes the idea that the compounds in cannabis have a synergistic interaction. This interaction encourages doctors to maintain a whole plant approach to cannabis medicine.
There are more than sixty identified cannabinoids found in the whole cannabis plant. Among them are the commonly referenced cannabidiol (CBD) and tetrahydrocannabinol (THC). On top of this there are hundreds of other chemical compounds like terpenes that are present in the plant. Each of these has its own benefits, but together cannabinoids accomplish even more.
This synergy is displayed by the powerful abilities of CBD. Taking a dab or vaping a strain with a THC content that is too high for us can cause anxiety sometimes verging on severe. A dropper filled with pure CBD hemp tincture can correct this endocannabinoid deficiency and bring anxiety levels back down. This can also help in those times when we may have eaten too many edibles.
Terpenes and cannabinoids surely have synergistic behavior that creates some of the medicinal and cherished effects of cannabis. This is why isolates and distillates don’t always do the job. Although the extraction industry is going crazy for isolated cannabinoids, it should be acknowledged that these compounds all work better together.
However, isolating the chemical compounds allows chemists to create combinations ideal for specific patients and ailments. Our knowledge of cannabinoids, terpenes, and the makeup of the cannabis plant will allow us to better treat patients. It will also help us better understand how to utilize the plant recreationally.